The Orthopedic industry continues to boom in Warsaw

Orthopedic industry booming in Warsaw (WNDU)
WARSAW, Ind. — While Northern Indiana is known as the RV Capital of the world, just an hour south of us, the orthopedic industry could give the RV industry a run for its money.
“The local companies here generate $17 billion in revenue annually,” Sheryl Conley, President & CEO of Orthoworx said. “It has $5 billion of impact to the state of Indiana on very many economic levels. It is critical to us. it is an industry that’s continuing to grow.”
For this growing industry, dozens of legislators came to Warsaw to hear about the economic boom it provides for the state.
“It’s increasingly known as the orthopedic implant capital of the world,” Chris Cerone, VP of Global Government Affairs for Zimmer Biomet said. “It’s a tremendous American success story. I have an opportunity to travel to other countries and one of the best things I do is talk about Warsaw and it’s importance to patients, health care and the importance to the economy of both Warsaw the region and the state and the US economy as well.”
While the industry is booming in Indiana and the country, it’s also big internationally and Warsaw is globally recognized as the hub of orthopedics devices.
“Having worked outside of the states, working in Ireland and having plants in china, the evolution is not as much as it is here,” Adrian Furey, VP of North America Operations for Zimmer Biomet said. “This is definitely where a lot of the core competencies are. It’s where their excellence is. I have no doubt there will be a fantastic future for orthopedics in Indiana.”
“From Warsaw to Ft. Wayne,” Conley said. “There are well over 10,000 jobs associated with this industry. This is the largest orthopedic medical device cluster in the world. Close to 50 percent of the total hips and knees are headquartered out of the companies here in this region. That’s a tremendous amount of impact worldwide.”
And to show the quality of the products made here in Warsaw, 29 year veteran orthopedic surgeon Dr. Mark Klaassen did a live knee replacement on a cadaver to show not just the speed of the surgery but how the products made in Warsaw can help change the quality of life for patients across the world.
“There is really none better in the world,” Dr. Klaassen said. “If you look, even though we may have some problems with our medical systems in terms of distribution, if you look at where people come to visit to see the best medical care in the world, they come to the United States. They come to watch surgery here. They come to watch the manufacturing here. They come to see the products here. I had five surgeons from Australia in my operating room on Monday. The quality of everybody else’s products is compared to what’s made here in Warsaw, Indiana.”
However, the success doesn’t come without challenges. The industry as a whole will need more employees; not a bad challenge to have. Ideas were floated out about getting into high schools and even middle schools in the state to inspire kids about the possibility of going into the industry of orthopedics. To those already in the industry, they feel it’s going to continue to be successful for years to come.
“We’re a part of an industry that is supported by incredible fundamentals, especially demographics,” Cerone said. “You have aging populations here and around the globe and they will continue to demand good, high quality products that will allow them to move freely and do what they do with their families and friends and their jobs.”

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Israeli startup will use PRP product to treat tennis elbow, ACL, rotator cuff, meniscus and cartilage

COLLPLANT: POSITIVE RESULTS FOR TENDINOPATHY PRODUCT (Orthopedics This Week)
CollPlant website
CollPlant Ltd., an Israeli regenerative medicine company, is announcing good things for its tendinopathy treatment product, VergenixSTR. The company, which is on schedule to receive CE mark approval for this product in the third quarter of 2016, uses plant-based technology.
As indicated in the August 17, 2016 news release, “The prospective, open label, single-arm trial was conducted at three leading Israeli hospitals (Meir Medical Center, Assaf Harofeh Medical Center and Hadassah Hospital), and the trial’s objective was to demonstrate the safety and performance of VergenixSTR in 40 patients suffering from inflammation of the elbow tendon, commonly referred to as tennis elbow. All patients were followed for a total of six months after a single treatment. Product performance was assessed by measuring reduction in pain and recovery of motion, as reported by the specific Patient Related Tennis Elbow Evaluation questionnaire (“PRTEE”).”

“At three months following treatment, VergenixSTR patients (N=39) reported an average PRTEE score improvement of 51% over baseline. At six-month follow-up, VergenixSTR patients (N=36) reported a mean PRTEE score improvement of 59% over baseline.”
“The performance of VergenixSTR also compared favorably to published results of corticosteroid injection, which is the standard-of-care therapy for tennis elbow. At three months following treatment, 74% of VergenixSTR patients reported a 25% or better PRTEE score improvement while, in the published controlled trial, 48% of steroid patients showed at least a 25% reduction in pain and disability. Further, at six month follow-up, 86% of VergenixSTR patients reported a 25% or better PRTEE score improvement, while 36% of steroid patients showed at least a 25% reduction in pain and disability.”
CollPlant CEO Yehiel Talof told OTW, “VergenixSTR is based on CollPlant’s proprietary plant-derived recombinant human collagen (rhCollagen). The product offers an effective treatment for tendinopathy by enabling a sustained release of PRP related growth factors (e.g., PDGF [plant-derived growth factor], VEGF [vascular endothelial growth factor]) at the injury site over a period of several weeks. VergenixSTR demonstrated excellent outcome in the clinical study for the treatment of tendonitis.
“In addition to tendinopathy, we plan on expanding the indications to intraoperative procedures such as partial/full tendon ruptures (e.g., ACL [anterior cruciate ligament], RCR [rotator cuff repair]), meniscus and cartilage repair. CollPlant is currently developing a BioInk for 3D bio printing of tissues and organs which is based on the rhCollagen platform. Another activity is development of hard tissue repair product which enables sustained release of growth factor for spinal fusion and trauma indications.”

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Delaying knee replacement with miniature sustained-release steroid implants

STEROID INFUSION IMPLANT TESTED AT HSS (Orthopedics This Week)
http://www.psivida.com/  “pSivida is a leading provider of miniaturized, sustained-release drug delivery products”
The pSivida Corporation and Hospital for Special Surgery, New York, are initiating an investigation into a sustained–release implant to treat severe knee osteoarthritis. According to the August 1, 2016 news release, the implant device is designed to provide long-term pain relief for patients with severe knee osteoarthritis. Physicians will implant the device into the non-articulating part of the knee during an outpatient procedure.
Researchers will evaluate the implant for six months. Pain relief after a single treatment is expected to extend for up to one year or more. The open-label, single-dose, safety and tolerability study will assess the ability of the implant to administer dexamethasone. Each of the six patients in the study will have the device implanted in one knee. Each week, investigators will assess change from baseline in mean of pain intensity scores at rest, with activity and at night through 24 weeks.
“We believe this product has the potential to provide long-term pain relief and to contribute to improved joint function for patients with severe osteoarthritis, which can delay knee replacement surgery,” said Robert N. Hotchkiss, M.D.,medical director of clinical research at Hospital for Special Surgery.
“Implanting a small, secure reservoir that delivers a corticosteroid on a sustained basis directly to the knee could avoid the issues with systemic steroid delivery and repetitive knee injections. This implant, the result of the combined insights [from] HSS and the expertise of pSivida, has the potential to create a paradigm shift in a variety of conditions.”

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The Top 10 Orthopedic Device Companies

Top 10 Orthopedic Device Companies (ODTMag)
Digital health has been making headlines for several years now, but it’s finally starting to be reflected in ODT’s Top 10.

While previously the focus of smaller firms and startups, industry giants like DePuy Synthes are putting forth a vision that more closely reflects those of its less influential peers. The implementation of strategies that involve cloud-based solutions, connectivity, and patient data tracking software is a significant step forward in the evolution of 21st-century healthcare. DePuy dipped its toe in this growing digital pool with the 2015 debut of two software systems that track and analyze patient data in real-time, and aim to improve patients’ experience with joint replacement surgery.
“The emerging field of health tech marries traditional medtech (e.g., medical devices) with state-of-the-art consumer electronics technology, digital marketing, e-commerce, and social media tools to create an entirely new class of products and solutions. Where traditional medtech catered exclusively to physicians and hospital systems, health tech is more likely to be consumer-facing, bringing new tools and technologies directly to patients. It’s also more focused on preventive care, enabling patients to better manage their health before their physical problems advance to a state that can only be treated via an intervention such as surgery,” Josh Makower, M.D., a general partner with venture capital firm New Enterprise Associates, said in EY’s 2015 Pulse of the Industry report.
To read the full feature, see it at ODTmag – Top 10 Orthopedic Device Companies

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The recycling solution for cremated Orthopedic Implants

THE AFTERLIFE OF CREMATED ORTHOPEDIC IMPLANTS (Orthopedics This Week)
website… OrthoMetals
What happens to joint replacements after an individual is cremated?
Adelaide reporter Brett Williamson reported on how that situation is dealt with in Australia. According to the Australian Institute of Health and Welfare a total of 72,551 hip and knee replacement operations were performed in Australia in 2013-2014.
Following a cremation, Williamson reported, staff run a magnet over the ashes to remove any metal. However, because titanium does not melt down, the replacement joints must be removed manually. Twice a year the local crematoriums in Australia send their retrieved joints to Melbourne where they are combined into one big shipment that is sent to the Netherlands.
Williamson said that there is a company called OrthoMetals that has a recycling facility for metals that come from implanted joint replacements. In one year the Dutch company does just over five tons of recycled metals. The service is provided free of charge to crematoriums and every six months a percentage of revenue raised from the recycled metals is given back. Williamson reported that the Adelaide Cemetery Association receives about $12,000 a year from the recycling program.
While devices made of metal are relatively harmless to pass through the cremation process, others, such as pacemakers, can be dangerous and can explode. Robert Pitt, chief executive of the Adelaide Cemeteries Authority, said, “The exploding battery can do quite a lot of damage inside a cremator and makes a very loud noise if it is not removed.”

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